Key Eligibility Requirements

  • Are 12 to 75 years old at the time of consent
  • Have a diagnosis of hemophilia A or B
  • Are on prophylactic therapy for their bleeding disorder or are willing to take gastroprotective medication provided by the study
  • Have had a diagnosis of hemophilic arthropathy for at least 6 months prior to screening, with history of joint bleeding and the primary source of disability in the knee, hip, ankle, shoulder, or elbow
  • Have chronic symptomatic pain in one or more joints on 20 of the 30 days prior to screening
  • Are willing to discontinue concomitant NSAIDs or opioid pain medications 7 days prior to randomization (can remain on acetaminophen)
  • Are willing to discontinue use of concomitant cannabinoids, benzodiazepines, and gabapentin /pregabalin as well as topical analgesics 7 days prior to study initiation and throughout study duration
  • Are taking long-acting opioids or short-acting opioids for greater than 4 days per week in the 30 days prior to screening
  • Have a history of asthma, allergies, or allergic-type reactions after taking aspirin or other NSAIDs
  • Have a history of advanced renal disease (estimated GFR <30 mL/min)
  • Has active hepatitis C or active hepatitis B infection or uncontrolled HIV
  • Currently have uncontrolled or poorly controlled hypertension
  • Have a history of major cardiac symptoms or events, or cerebrovascular events (TIA or stroke)
  • Have a history of a major upper GI event (upper GI perforation, obstruction, or major upper GI bleeding) prior to screening
  • Have a had an episode of major depression or suicide event within 6 months prior to screening

For a complete list of study eligibility criteria, please fill out our contact form.


We Look Forward to Speaking to You

If you would like more information about the RESET-HA study, including how to refer a patient or to be considered as a principal investigator, please fill out our form below.

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