Eligibility

Inclusion Criteria

Are 12 to 75 years old at the time of consent
Have a diagnosis of hemophilia A or B
Are on prophylactic therapy for their bleeding disorder or are willing to take gastroprotective medication provided by the study
Have had a diagnosis of hemophilic arthropathy for at least 6 months prior to screening, with history of joint bleeding and the primary source of disability in the knee, hip, ankle, shoulder, or elbow
Have chronic symptomatic pain in one or more joints on 20 of the 30 days prior to screening
Are willing to discontinue concomitant NSAIDs or opioid pain medications 7 days prior to randomization (can remain on acetaminophen)
Are willing to discontinue use of concomitant cannabinoids, benzodiazepines, and gabapentin /pregabalin as well as topical analgesics 7 days prior to study initiation and throughout study duration

Exclusion Criteria

Are taking long-acting opioids or short-acting opioids for greater than 4 days per week in the 30 days prior to screening
Have a history of asthma, allergies, or allergic-type reactions after taking aspirin or other NSAIDs
Have a history of advanced renal disease (estimated GFR <30 mL/min)
Has active hepatitis C or active hepatitis B infection or uncontrolled HIV
Currently have uncontrolled or poorly controlled hypertension
Have a history of major cardiac symptoms or events, or cerebrovascular events (TIA or stroke)
Have a history of a major upper GI event (upper GI perforation, obstruction, or major upper GI bleeding) prior to screening
Have a had an episode of major depression or suicide event within 6 months prior to screening

For a complete list of study eligibility criteria, please fill out our contact form.

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Key Eligibility Requirements